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Text http://ns.adobe.com/xap/1.0/mm/ Text converted Text See this image and copyright information in PMC. endobj Direct formation of amides assisted by TiCl 4, Proposed mechanism for the TiCl 4 assisted direct amidation, Direct formation of enantiomeric amides 27 – 28 assisted by TiCl 4, Chiral GC/MS analyses of crude amides 27 and 28 : a (S)-2-( N…, NLM 2017-09-15T15:11:12+02:00


"http://dx.doi.org/10.1186/s13065-017-0318-9 Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) Text If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. InstanceID Angelo Liguori SourceModified

doi Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides. 2 0 obj DOI external EVoR = Enhanced Version of Record Text 5 0 obj


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A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl4 is reported.

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Analysis of the reactions used for the preparation of drug candidate molecules. Epub 2018 Dec 6. http://www.aiim.org/pdfa/ns/id/ Tetrahedron.

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Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” Recent Advances in the Metal-Catalyzed Activation of Amide Bonds.

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The direct conversion of a carboxylic acid to an amide is difficult because amines are basic and tend to convert carboxylic acids to their highly unreactive carboxylates.

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