In Hawaii, it has been calculated that manual picking and field sorting constitute 40% of the labor cost of the crop (1,702 man-hours per acre to pick and pack). Bunchy top can be distinguished from boron deficiency by the fact that the tops of affected plants do not ooze latex when pricked. Rhizopus oryzae is most commonly linked with rotting fruits on Pakistan markets. It was named 'Solo' in 1919 and by 1936 was the only commercial papaya in the islands.

Stem-end rot occurs when fruits are pulled, not cut, from the plant and the fungus, Ascochyta caricae, is permitted entrance. Fungicidal sprays and removal of diseased plants and fruits will reduce the incidence. Germination may take 3 to 5 weeks. Treatment at 100 krads slightly accelerated ripening in storage. Sulfur, judiciously applied, is an effective control. In Hawaii, 'Solo' grafted onto 'Dwarf Solo' was reduced in vigor and productivity, but 'Dwarf Solo' grafted onto 'Solo' showed improved performance. They are watered daily and transplanted in 2 1/2 months when 6 to 8 in (15-20 cm) high.

At the Agricultural Research and Education Center of the University of Florida in Homestead, the late Dr. Robert Conover established a test plot of papayas grown from seed of 95 accessions from a number of countries and 94 collections in Florida in the hope of finding some virus-free strains. Once rooted, the cuttings are planted in plastic bags and kept under mist for 10 days, and then put in a shade house for hardening before setting in the field. One man can thus gather 800-1,000 lbs (363-454 kg) daily. The latex oozing from the stem may irritate the skin and workers should be required to wear gloves and protective clothing. Unripe papaya is never eaten raw because of its latex content. The seeds are sown 2 in (5 cm) apart and 3/4 to 1 1/8 in (2-3 cm) deep in rows 6 in (15 cm) apart. From 250 acres (100 ha), Princess Orchards on Maui harvests 150,000 lbs (68,180 kg) weekly during the season. Papain has many other practical applications. In French, it is papaye (the fruit) and papayer (the plant), or sometimes figuier des Iles. Mention is made later on of the aphids that transmit virus diseases and other infections. This pest and the cucumber fly and fruit-spotting bugs feed on the very young fruits and cause them to drop. The latex coagulates quickly and, for best results, is spread on fabric and oven-dried at a low temperature, then ground to powder and packed in tins. A yellow to brown, faintly scented oil was extracted from the sundried, powdered seeds of unripe papayas at the Central Food Technological Research Institute, Mysore, India. Other pests requiring control measures in Australia include the red spider, or red spider mite, Tetranychus seximaculatus, which sucks the juice from the leaves.
To cross-pollinate, one or 2 stamens from a bisexual flower are placed on the pistil of a female flower about to open and a bag is tied over the flower for a few days.

They hasten the demise of plants afflicted with stem rot from Pythium aphanidermatum and may act as vectors for this fungus. This melon-like fruit varies in size and shape and is not only delicious, but it is very good for you. The latest trend and news right now is Oprah purchased an Avocado Orchard because “"It... Avocado Recall: Who’s Responsible? Unfortunately, your browser does not support modern technology used on our website. Damage can be prevented if spraying is begun at the beginning of fruit set, or at least at the first sign of webs. Attached lightly to the wall by soft, white, fibrous tissue, are usually numerous small, black, ovoid, corrugated, peppery seeds about 3/16 in (5 mm) long, each coated with a transparent, gelatinous aril. Both forms occur in some northcoast plantations. Papaya do not like wet feet and must have very well drained soil. The female deposits eggs in the fruit which will later be found infested with the larvae. Sometimes a few seeds are left attached for those who enjoy their peppery flavor but not many should be eaten. The latter is most abundant but papain is twice as potent. Successful commercial production today is primarily in Hawaii, tropical Africa, the Philippines, India, Ceylon, Malaya and Australia, apart from the widespread but smaller scale production in South Africa, and Latin America. Some growers insist on an 8 x 8 ft (2.4 x 2.4 m) area per plant.

Seeds were sent from India to Naples in 1626.

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